How can we preserve human agency while managing the cascading risks of technological dependence? Sylvie di Giusto explores the critical connections between technological advancement and human vulnerability, guiding leaders in identifying and mitigating the systemic risks that threaten our humanity in an increasingly automated world. As automation, AI, mixed realities, and robotics create unprecedented interdependencies in the workplace and society, we face a complex matrix of emerging risks. These technologies not only change how we work; they fundamentally alter human behavior, creating cascading effects that ripple through trust networks, decision-making processes, and social connections. The risks are interconnected: technological dependence can lead to cognitive atrophy, algorithmic mediation undermines authentic relationships, and digital interfaces can reduce our capacity for nuanced human judgment. Today's professionals navigate a landscape where employees and clients are simultaneously more informed yet less discerning, more connected yet isolated, more empowered yet more vulnerable to manipulation. These paradoxes create systemic vulnerabilities that leaders must recognize and address. The future belongs to those who can map and manage this risk matrix, understanding how technological disruption in one area can cascade into human challenges in another. Leaders who comprehend these interconnected risks can build resilient organizations that embrace innovation while safeguarding the irreplaceable elements of human connection and judgment, which remain our most significant competitive advantage.